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Metastatic Neuroblastoma

MedGen UID:
1660128
•Concept ID:
C4722306
•
Neoplastic Process

Definition

A neuroblastoma that has metastasized from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Neuroblastoma

Professional guidelines

PubMed

Targeting B7-H3-A Novel Strategy for the Design of Anticancer Agents for Extracranial Pediatric Solid Tumors Treatment.
Rasic P, Jeremic M, Jeremic R, Dusanovic Pjevic M, Rasic M, Djuricic SM, Milickovic M, Vukadin M, Mijovic T, Savic D
Molecules 2023 Apr 11;28(8) doi: 10.3390/molecules28083356. PMID: 37110590Free PMC Article
Mechanisms, Characteristics, and Treatment of Neuropathic Pain and Peripheral Neuropathy Associated with Dinutuximab in Neuroblastoma Patients.
Mastrangelo S, Rivetti S, Triarico S, Romano A, Attinà G, Maurizi P, Ruggiero A
Int J Mol Sci 2021 Nov 23;22(23) doi: 10.3390/ijms222312648. PMID: 34884452Free PMC Article
Incidence, Survival, and Treatment of Localized and Metastatic Neuroblastoma in Germany 1979-2015.
Berthold F, Spix C, Kaatsch P, Lampert F
Paediatr Drugs 2017 Dec;19(6):577-593. doi: 10.1007/s40272-017-0251-3. PMID: 28786082Free PMC Article

Recent clinical studies

Etiology

Risk factors and novel predictive models for metastatic neuroblastoma in children.
Lin Y, Wang Z, Liu S
Eur J Surg Oncol 2023 Dec;49(12):107110. Epub 2023 Oct 6 doi: 10.1016/j.ejso.2023.107110. PMID: 37862722
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
Role and toxicity of radiation therapy in neuroblastoma patients: A literature review.
Zhao Q, Liu Y, Zhang Y, Meng L, Wei J, Wang B, Wang H, Xin Y, Dong L, Jiang X
Crit Rev Oncol Hematol 2020 May;149:102924. Epub 2020 Mar 3 doi: 10.1016/j.critrevonc.2020.102924. PMID: 32172225
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov K, Cheung NK
Semin Oncol 2014 Oct;41(5):589-612. Epub 2014 Jul 21 doi: 10.1053/j.seminoncol.2014.07.003. PMID: 25440605Free PMC Article

Diagnosis

Risk factors and novel predictive models for metastatic neuroblastoma in children.
Lin Y, Wang Z, Liu S
Eur J Surg Oncol 2023 Dec;49(12):107110. Epub 2023 Oct 6 doi: 10.1016/j.ejso.2023.107110. PMID: 37862722
Phase 1 study of intraventricular (131)I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kramer K, Pandit-Taskar N, Kushner BH, Zanzonico P, Humm JL, Tomlinson U, Donzelli M, Wolden SL, Haque S, Dunkel I, Souweidane MM, Greenfield JP, Tickoo S, Lewis JS, Lyashchenko SK, Carrasquillo JA, Chu B, Horan C, Larson SM, Cheung NV, Modak S
J Hematol Oncol 2022 Nov 12;15(1):165. doi: 10.1186/s13045-022-01383-4. PMID: 36371226Free PMC Article
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
p53 family: Therapeutic targets in neuroblastoma.
Wolter J, Angelini P, Irwin M
Future Oncol 2010 Mar;6(3):429-44. doi: 10.2217/fon.09.176. PMID: 20222799
Disialoganglioside directed immunotherapy of neuroblastoma.
Modak S, Cheung NK
Cancer Invest 2007 Feb;25(1):67-77. doi: 10.1080/07357900601130763. PMID: 17364560

Therapy

Phase 1 study of intraventricular (131)I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kramer K, Pandit-Taskar N, Kushner BH, Zanzonico P, Humm JL, Tomlinson U, Donzelli M, Wolden SL, Haque S, Dunkel I, Souweidane MM, Greenfield JP, Tickoo S, Lewis JS, Lyashchenko SK, Carrasquillo JA, Chu B, Horan C, Larson SM, Cheung NV, Modak S
J Hematol Oncol 2022 Nov 12;15(1):165. doi: 10.1186/s13045-022-01383-4. PMID: 36371226Free PMC Article
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells.
Shum T, Omer B, Tashiro H, Kruse RL, Wagner DL, Parikh K, Yi Z, Sauer T, Liu D, Parihar R, Castillo P, Liu H, Brenner MK, Metelitsa LS, Gottschalk S, Rooney CM
Cancer Discov 2017 Nov;7(11):1238-1247. Epub 2017 Aug 22 doi: 10.1158/2159-8290.CD-17-0538. PMID: 28830878Free PMC Article
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov K, Cheung NK
Semin Oncol 2014 Oct;41(5):589-612. Epub 2014 Jul 21 doi: 10.1053/j.seminoncol.2014.07.003. PMID: 25440605Free PMC Article

Prognosis

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Risk factors and novel predictive models for metastatic neuroblastoma in children.
Lin Y, Wang Z, Liu S
Eur J Surg Oncol 2023 Dec;49(12):107110. Epub 2023 Oct 6 doi: 10.1016/j.ejso.2023.107110. PMID: 37862722
Phase 1 study of intraventricular (131)I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kramer K, Pandit-Taskar N, Kushner BH, Zanzonico P, Humm JL, Tomlinson U, Donzelli M, Wolden SL, Haque S, Dunkel I, Souweidane MM, Greenfield JP, Tickoo S, Lewis JS, Lyashchenko SK, Carrasquillo JA, Chu B, Horan C, Larson SM, Cheung NV, Modak S
J Hematol Oncol 2022 Nov 12;15(1):165. doi: 10.1186/s13045-022-01383-4. PMID: 36371226Free PMC Article
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S
Nat Commun 2021 Jan 21;12(1):511. doi: 10.1038/s41467-020-20785-x. PMID: 33479234Free PMC Article

Clinical prediction guides

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Risk factors and novel predictive models for metastatic neuroblastoma in children.
Lin Y, Wang Z, Liu S
Eur J Surg Oncol 2023 Dec;49(12):107110. Epub 2023 Oct 6 doi: 10.1016/j.ejso.2023.107110. PMID: 37862722
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S
Nat Commun 2021 Jan 21;12(1):511. doi: 10.1038/s41467-020-20785-x. PMID: 33479234Free PMC Article
Establishment and characterization of new orthotopic and metastatic neuroblastoma models.
Daudigeos-Dubus E, LE Dret L, Rouffiac V, Bawa O, Leguerney I, Opolon P, Vassal G, Geoerger B
In Vivo 2014 Jul-Aug;28(4):425-34. PMID: 24982206
Disialoganglioside directed immunotherapy of neuroblastoma.
Modak S, Cheung NK
Cancer Invest 2007 Feb;25(1):67-77. doi: 10.1080/07357900601130763. PMID: 17364560

Recent systematic reviews

Incidence of subclinical and overt hypothyroidism in children treated with [131I]mIBG: a systematic review and meta-analysis.
Fiz F, Piticchio T, Bottoni G, Sorrentino S, Fragola M, Livellara V, Trimboli P, Piccardo A
Q J Nucl Med Mol Imaging 2024 Mar;68(1):40-47. Epub 2024 Feb 6 doi: 10.23736/S1824-4785.24.03552-0. PMID: 38319674

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